Ethyl 1,2,4-triazolo[4,3-a]pyrazine-3-carboxylate
1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ethyl ester
CAS: 723286-67-7
Molecular Formula: C8H8N4O2
Ethyl 1,2,4-triazolo[4,3-a]pyrazine-3-carboxylate - Names and Identifiers
Ethyl 1,2,4-triazolo[4,3-a]pyrazine-3-carboxylate - Physico-chemical Properties
| Molecular Formula | C8H8N4O2 |
| Molar Mass | 192.17 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| pKa | -2.12±0.30(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | IRRITANT |
| MDL | MFCD09909674 |
Ethyl 1,2,4-triazolo[4,3-a]pyrazine-3-carboxylate - Introduction
1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ester is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Chemical formula: C10H8N4O2
-Molecular weight: 224.20g/mol
-Appearance: Colorless crystalline solid
-Melting point: 112-116°C
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide
Use:
- 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ethyl ester is widely used in medicinal chemistry and medicine.
-It can be used as an intermediate for the synthesis and modification of drug molecules for the synthesis of biologically active compounds.
-The compound can also be used as a raw material for antiviral and antitumor drugs.
Preparation Method:
- 1,2,4-Triazolo[4,3-a] There are many ways to synthesize pyrazine-3-carboxylic acid ethyl ester. The following is a common method:
1. First, under alkaline conditions, 1-cyclopropyl -1H-tetrazole and 2-bromoethyl acetate are esterified to generate 1,2, 4-triazolo [4,3-a] pyrazine -3-acid ethyl ester.
2. Then, the resulting acid ethyl ester is reacted with an alcohol solution to obtain 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ethyl ester.
Safety Information:
- 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ethyl ester is generally safe under normal operating conditions.
-However, as a chemical substance, it still has certain potential risks.
-Wear appropriate protective equipment such as lab gloves and safety glasses during operation.
-Avoid inhaling the dust or gas of the compound, and make sure to work in a well-ventilated place.
-When using or handling, please follow the relevant safety operation guidelines and recommendations.
Nature:
-Chemical formula: C10H8N4O2
-Molecular weight: 224.20g/mol
-Appearance: Colorless crystalline solid
-Melting point: 112-116°C
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide
Use:
- 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ethyl ester is widely used in medicinal chemistry and medicine.
-It can be used as an intermediate for the synthesis and modification of drug molecules for the synthesis of biologically active compounds.
-The compound can also be used as a raw material for antiviral and antitumor drugs.
Preparation Method:
- 1,2,4-Triazolo[4,3-a] There are many ways to synthesize pyrazine-3-carboxylic acid ethyl ester. The following is a common method:
1. First, under alkaline conditions, 1-cyclopropyl -1H-tetrazole and 2-bromoethyl acetate are esterified to generate 1,2, 4-triazolo [4,3-a] pyrazine -3-acid ethyl ester.
2. Then, the resulting acid ethyl ester is reacted with an alcohol solution to obtain 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ethyl ester.
Safety Information:
- 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid ethyl ester is generally safe under normal operating conditions.
-However, as a chemical substance, it still has certain potential risks.
-Wear appropriate protective equipment such as lab gloves and safety glasses during operation.
-Avoid inhaling the dust or gas of the compound, and make sure to work in a well-ventilated place.
-When using or handling, please follow the relevant safety operation guidelines and recommendations.
Last Update：2024-04-09 21:01:54
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